AMZ2抗体 新品

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P07877(AMZ2 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07877(AMZ2 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

AMZ2 (Archipelago Homolog 2), also known as RNF216P1. is a gene encoding a protein with a RING finger domain, suggesting its potential role in ubiquitination and protein degradation processes. Initially identified through homology to the Drosophila archipelago gene, AMZ2 is implicated in regulating cell cycle progression and signal transduction pathways. Studies indicate its interaction with components of the E3 ubiquitin ligase complex, which targets specific proteins for proteasomal degradation, influencing cellular processes like apoptosis and proliferation.

Research on AMZ2 has gained attention due to its possible involvement in neurological disorders and cancer. For instance, dysregulation of AMZ2 expression has been observed in certain tumors, linking it to oncogenic or tumor-suppressive roles depending on cellular context. Additionally, its homolog RNF216 is associated with neurodegenerative conditions like Gordon Holmes syndrome, hinting at AMZ2's potential relevance in neural health.

The AMZ2 antibody is a critical tool for investigating these functions. It enables detection and quantification of AMZ2 protein levels in tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Researchers use it to explore AMZ2's localization, interaction partners, and expression patterns under various physiological or pathological conditions. Its development supports ongoing efforts to clarify AMZ2's mechanistic contributions to disease pathways and therapeutic potential.