APTX抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07873(APTX Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07873(APTX Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

Aptx (Aprataxin) is a DNA repair protein encoded by the *APTX* gene, primarily associated with maintaining genomic stability by resolving abortive DNA ligation intermediates during single-strand break (SSB) repair. Mutations in *APTX* are linked to autosomal recessive neurodegenerative disorders, notably ataxia-oculomotor apraxia 1 (AOA1) and spinocerebellar ataxia. The protein contains conserved HIT (histidine triad) and zinc-finger domains critical for its enzymatic activity in hydrolyzing 5′-adenylate adducts at DNA termini, enabling error-free repair.

APTX antibodies are essential tools in studying its role in DNA repair mechanisms, disease pathology, and cellular localization. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect APTX expression levels in tissues or cultured cells. Research applications include investigating APTX dysfunction in neurodegeneration, cancer (where APTX loss may impair genome integrity), and its interplay with other repair proteins like XRCC1. Commercially available APTX antibodies are typically raised against specific epitopes, such as N-terminal or C-terminal regions, with validation in knockout models to ensure specificity. Recent studies also explore APTX's potential as a biomarker or therapeutic target, emphasizing the antibody's dual utility in diagnostic and basic research contexts.