APPBP2抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07872(APPBP2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07872(APPBP2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The APPBP2 (Amyloid Beta Precursor Protein Binding Protein 2) antibody is a tool used to study the APPBP2 protein, which plays diverse roles in cellular processes. APPBP2. also known as PAT1 (Protein Associated with TOP mRNA), was initially identified through its interaction with the amyloid precursor protein (APP), a key player in Alzheimer’s disease pathogenesis. Beyond APP binding, APPBP2 is implicated in intracellular trafficking, mRNA regulation, and signaling pathways, including interactions with the mTOR complex, suggesting roles in cell growth and autophagy.

The antibody enables detection of APPBP2 in techniques like Western blot (WB), immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP). Researchers use it to investigate APPBP2 expression patterns across tissues, subcellular localization (cytoplasmic/nuclear), and dysregulation in diseases. For instance, APPBP2 is studied in neurodevelopmental disorders, cancers (e.g., breast, liver), and neurodegeneration due to its links to apoptosis and cell cycle control.

Validation of APPBP2 antibodies often involves knockout cell lines to confirm specificity, as isoforms or post-translational modifications may affect detection. Observed molecular weight ranges (~65-70 kDa) may vary due to splice variants. Its role in mTOR signaling and APP processing makes it relevant for therapeutic research, particularly in contexts like Alzheimer’s, cancer progression, and metabolic disorders.