STAMBP抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07843(STAMBP Antibody) at dilution 1/15. (Original magnification: ×200)    

  
  

The STAMBP (Signal Transducing Adaptor Molecule Binding Protein) antibody is a tool used to detect and study the STAMBP protein, a deubiquitinating enzyme involved in intracellular signaling and protein trafficking. STAMBP, also known as AMSH (Associated Molecule with the SH3 Domain of STAM), plays a critical role in the endosomal sorting pathway by cleaving ubiquitin from ubiquitinated proteins, influencing receptor recycling or degradation via multivesicular bodies (MVBs). This protein interacts with STAM1/2 adaptors, linking it to growth factor and cytokine signaling pathways, including EGFR and interferon responses.

STAMBP antibodies are essential in research to investigate its expression, localization, and function in cellular processes. Dysregulation of STAMBP is linked to neurological disorders, particularly microcephaly-capillary malformation syndrome (MIC-CAP), caused by STAMBP mutations. Studies also explore its role in cancer, immune regulation, and neurodegenerative diseases like Alzheimer’s, where defective protein sorting may contribute to pathology. By enabling techniques like Western blot, immunohistochemistry, and immunofluorescence, these antibodies help elucidate STAMBP’s molecular mechanisms and potential as a therapeutic target.