AMDHD2抗体

The AMDHD2 (Adenylate and Methylthiohydrolase Domain-containing Protein 2) antibody is a research tool used to study the AMDHD2 protein, which plays a role in nucleotide metabolism. AMDHD2 is a conserved enzyme involved in the methionine salvage pathway, catalyzing the hydrolysis of methylthioadenosine (MTA) and other adenine derivatives. This pathway is critical for recycling sulfur-containing metabolites and maintaining cellular homeostasis. Dysregulation of AMDHD2 has been linked to metabolic disorders and cancer progression, as altered nucleotide metabolism is a hallmark of tumorigenesis. The AMDHD2 antibody enables detection and quantification of the protein in various experimental settings, such as Western blotting, immunohistochemistry, and immunofluorescence. It aids in investigating AMDHD2's expression patterns, subcellular localization, and interactions in normal and diseased tissues. Researchers utilize this antibody to explore its potential as a biomarker or therapeutic target, particularly in oncology. Commercially available AMDHD2 antibodies are typically raised in rabbits or mice using recombinant protein fragments or synthetic peptides. Validation data, including knockout cell line controls, are essential to confirm specificity. Studies employing this antibody contribute to understanding metabolic adaptations in proliferating cells and AMDHD2's role in health and disease.