ACTA1抗体 新品

+ +

•  

   

     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse muscle tissue, Mouse heart tissue, Primary antibody: P07830(ACTA1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07830(ACTA1 Antibody) at dilution 1/65. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07830(ACTA1 Antibody) at dilution 1/65. (Original magnification: ×200)    

  
  

The ACTA1 antibody is a tool used to detect alpha-skeletal muscle actin, a protein encoded by the ACTA1 gene. This gene, located on chromosome 1q42.13. is predominantly expressed in skeletal muscle, where it plays a critical role in contractile function by forming the core of thin filaments in sarcomeres. ACTA1 mutations are linked to various congenital myopathies, including nemaline myopathy, actin-accumulation myopathy, and congenital fiber-type disproportion.

ACTA1 antibodies are widely employed in research and diagnostics to study muscle development, regeneration, and pathology. They help identify abnormal protein aggregates, assess actin expression levels, or confirm skeletal muscle-specific cell differentiation in vitro. Commercially available ACTA1 antibodies are typically monoclonal or polyclonal, validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence.

In clinical contexts, ACTA1 antibodies aid in diagnosing muscle biopsies from patients with unexplained weakness or structural abnormalities. They distinguish skeletal muscle actin isoforms from cardiac (ACTC1) or smooth muscle (ACTA2) variants, ensuring accurate subtype classification of myopathies. Recent studies also explore ACTA1’s role in cancer metastasis, as actin dynamics influence cell motility. However, cross-reactivity with other actin isoforms remains a technical challenge, requiring careful validation. Overall, ACTA1 antibodies are indispensable for advancing muscle biology research and improving diagnostic precision in neuromuscular disorders.