AGFG1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: A172 cells, Hela cells, 293T cells, K562 cells, human testis tissue, Primary antibody: P07798(AGFG1 Antibody) at dilution 1/533, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07798(AGFG1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07798(AGFG1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The AGFG1 antibody is a research tool designed to detect ArfGAP with FG repeats 1 (AGFG1), a protein involved in intracellular trafficking and RNA metabolism. AGFG1. also known as HRB or RAB, functions as a cofactor in nuclear export of unspliced viral RNAs, particularly in HIV-1 replication, by interacting with the viral Rev protein and the CRM1 export machinery. It contains an ArfGAP domain and FG repeats, enabling roles in vesicle formation, nucleocytoplasmic transport, and mRNA processing.

AGFG1 antibodies are commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to study AGFG1’s expression, localization, and interactions in cellular models. These antibodies aid in exploring AGFG1’s contributions to viral pathogenesis, cancer progression (e.g., leukemia, breast cancer), and neurological disorders, as dysregulation of AGFG1 is linked to altered RNA transport and signaling pathways.

Most AGFG1 antibodies are raised in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions). Validation includes testing on knockout cell lines or tissues to ensure specificity. Commercial antibodies often provide data across human, mouse, and rat samples. Research utilizing AGFG1 antibodies continues to clarify its dual roles in viral replication and cellular homeostasis, highlighting its potential as a therapeutic target.