AGBL3抗体 新品

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue lysate, Primary antibody: P07797(AGBL3 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07797(AGBL3 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The AGBL3 (ATP/GTP Binding Protein-Like 3) antibody is a tool used to detect the AGBL3 protein, a member of the cytosolic carboxypeptidase (CCP) family. AGBL3. also known as CCP3. is a metalloprotease implicated in post-translational protein modification, particularly in the removal of C-terminal amino acids like glutamates or aspartates. This enzymatic activity is critical for regulating protein function, stability, and interactions. AGBL3 is closely related to other CCP family members, such as AGBL1 and AGBL2. which are involved in neuronal tubulin detyrosination—a process essential for microtubule dynamics and cellular processes like division and trafficking.

Research on AGBL3 is less extensive compared to its homologs, but studies suggest its potential role in cytoskeletal regulation and neurological functions. It is expressed in various tissues, including the brain, testis, and liver. Dysregulation of CCP family enzymes has been linked to neurodegenerative diseases and cancer, though AGBL3-specific mechanisms remain under investigation. The AGBL3 antibody is utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its expression, localization, and biological significance. Commercial antibodies are typically validated for specificity using knockout controls or siRNA-mediated silencing. Researchers employ this tool to explore AGBL3's involvement in cellular pathways, disease models, or as a biomarker, emphasizing the need for rigorous validation to ensure target specificity in experimental settings.