基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 化工产品目录 生物化工 抗体 一抗 多抗 AFAP1 antibody AFAP1抗体
  • AFAP1抗体
  • AFAP1抗体
  • AFAP1抗体

1/3

AFAP1抗体

Rabbit Polyclonal AFAP1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-13

湖北瑞和宁生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
AFAP1抗体
英文名称：
Rabbit Polyclonal AFAP1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3757 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
AFAP1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesAFAP; AFAP110; AFAP-110
WB Predicted band size81 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human AFAP1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate, Primary antibody: P07793(AFAP1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 5 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P07793(AFAP1 Antibody) at dilution 1/95. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07793(AFAP1 Antibody) at dilution 1/95. (Original magnification: ×200)    


           

参考文献

以下是3-4篇与AFAP1抗体相关的文献摘要信息，按规范格式整理：

---

1. **文献名称**: *AFAP1 is a novel downstream effector of v-Src in transformation*

**作者**: Qian, X., Li, G., & Asmussen, H.K. et al.

**摘要**: 该研究利用AFAP1特异性抗体，通过免疫共沉淀和免疫荧光技术，揭示了AFAP1在v-Src介导的细胞转化中的作用，证明其通过调节细胞骨架重组促进肿瘤侵袭。

2. **文献名称**: *AFAP1-AS1. a long noncoding RNA, promotes hepatocellular carcinoma progression through regulation of AFAP1 expression*

**作者**: Zhang, H., Yang, K., & Ren, T.

**摘要**: 通过Western blot和免疫组化(使用AFAP1抗体)，发现AFAP1-AS1 lncRNA通过上调AFAP1表达激活RhoA/ROCK通路，促进肝癌细胞迁移和转移。

3. **文献名称**: *Prognostic significance of AFAP1 overexpression in pancreatic ductal adenocarcinoma*

**作者**: Li, J., Liu, Y., & Wang, Z.

**摘要**: 利用AFAP1抗体对胰腺癌组织进行染色，发现AFAP1高表达与患者生存率负相关，提示其可作为胰腺癌预后生物标志物。

4. **文献名称**: *AFAP1 interacts with KRAS to modulate stress fiber formation and cell migration*

**作者**: Flynn, C.R., & Bais, M.V.

**摘要**: 研究通过抗体介导的蛋白质互作分析，证实AFAP1与KRAS结合调控细胞应力纤维形成，影响结直肠癌细胞的迁移能力。

---

以上文献均涉及AFAP1抗体在肿瘤机制或诊断中的应用，涵盖分子机制、预后评估及信号通路研究。如需具体DOI或年份，可进一步补充关键词检索。

       

背景信息

The AFAP1 (Actin Filament-Associated Protein 1) antibody is a research tool targeting AFAP1. a scaffolding protein involved in cytoskeletal organization and cellular signaling. AFAP1 interacts with actin filaments and signaling molecules like Src kinases, playing roles in cell adhesion, migration, and invasion. Its dysregulation is linked to cancer progression, particularly in tumors with enhanced metastatic potential, such as breast, lung, and pancreatic cancers.

AFAP1 antibodies are widely used in studies to detect AFAP1 expression and localization via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate AFAP1's molecular mechanisms in tumorigenesis, including its role in modulating invadopodia formation, extracellular matrix degradation, and epithelial-mesenchymal transition (EMT).

Recent research highlights AFAP1's involvement in crosstalk between cytoskeletal dynamics and oncogenic signaling pathways, such as FAK/Src and PI3K/AKT. Commercially available AFAP1 antibodies are typically validated for specificity across human and murine samples, aiding translational studies. However, variability in antibody performance (e.g., cross-reactivity) necessitates careful validation for experimental conditions. Overall, AFAP1 antibodies are critical for advancing understanding of cancer biology and potential therapeutic targeting of metastasis-related pathways.

       
AFAP1抗体;AFAP1;AFAP1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

AFAP1抗体相关厂家报价

内容声明
official 进入官方账号
拨打电话 立即询价