ADCK1抗体

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07782(ADCK1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07782(ADCK1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The ADCK1 (AarF domain-containing kinase 1) antibody is a research tool designed to detect and study the ADCK1 protein, a member of the mitochondrial kinase family involved in cellular energy metabolism and stress responses. ADCK1 is implicated in Coenzyme Q (CoQ) biosynthesis, a critical pathway for mitochondrial electron transport and antioxidant defense. It interacts with COQ protein complexes to regulate CoQ production, impacting cellular energy homeostasis.

ADCK1 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate ADCK1 expression, localization, and function in various tissues and disease models. These antibodies are essential for studying ADCK1's role in mitochondrial disorders, neurodegenerative diseases (e.g., Parkinson’s), and cancers, where dysregulated CoQ metabolism or mitochondrial dysfunction may contribute to pathology.

Validated antibodies typically target specific epitopes within ADCK1's conserved kinase or regulatory domains, ensuring specificity across species like humans, mice, and rats. Researchers rely on ADCK1 antibodies to explore its regulatory mechanisms, post-translational modifications, and interactions with other mitochondrial proteins. Such studies advance understanding of metabolic diseases and inform therapeutic strategies targeting mitochondrial pathways. Proper antibody validation via knockout controls or siRNA knockdown is crucial to confirm reliability in experimental settings.