ADAM30抗体

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07774(ADAM30 Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07774(ADAM30 Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

ADAM30 (A Disintegrin and Metalloproteinase 30) is a member of the ADAM family of transmembrane proteins, which are known for their roles in proteolytic processing, cell adhesion, and signal transduction. ADAM30 is encoded by the ADAM30 gene and shares structural features common to ADAM proteins, including a prodomain, metalloproteinase domain, disintegrin-like domain, and a cytoplasmic tail. While its precise physiological functions remain less characterized compared to other ADAMs (e.g., ADAM17 or ADAM10), emerging studies suggest its involvement in proteolytic processing of substrates within the extracellular matrix or cell surface receptors.

ADAM30 has garnered attention in neurodegenerative research due to its potential link to Alzheimer’s disease (AD). Studies indicate that ADAM30 may influence amyloid-beta (Aβ) peptide production by modulating the processing of amyloid precursor protein (APP), though its exact mechanism is under investigation. Additionally, ADAM30 is implicated in reproductive biology, with expression observed in testicular tissues, suggesting roles in sperm maturation or fertilization. Its expression in immune cells also hints at possible involvement in inflammatory responses.

Antibodies targeting ADAM30 are critical tools for elucidating its expression patterns, localization, and functional interactions. These antibodies enable techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding in the exploration of ADAM30’s roles in health and disease. Commercial availability of ADAM30 antibodies has facilitated research, though specificity and validation across experimental models remain essential considerations. Ongoing studies aim to clarify its therapeutic potential, particularly in neurodegenerative and reproductive disorders.