ACTR1A抗体

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07763(ACTR1A Antibody) at dilution 1/75. (Original magnification: ×200)    

  
  

The ACTR1A (ARP1 Actin-Related Protein 1A) antibody is a tool used to study the ACTR1A protein, a member of the actin-related protein (ARP) family. ACTR1A plays a critical role in cellular processes such as vesicle trafficking, organelle positioning, and cytoskeletal organization. It is a key component of the dynactin complex, which interacts with dynein motors to facilitate microtubule-based intracellular transport. ACTR1A shares structural homology with actin but lacks filament-forming ability, instead stabilizing dynactin’s structure and enhancing dynein-mediated cargo movement.

ACTR1A antibodies are widely employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression, localization, and dynamics in cells or tissues. These antibodies help researchers investigate ACTR1A’s involvement in mitosis, neuronal transport, and cell migration. Dysregulation of ACTR1A has been linked to neurodegenerative diseases, cancer metastasis, and developmental disorders, making its study clinically relevant.

Most ACTR1A antibodies are raised against specific epitopes, such as the N- or C-terminal regions, and are available in monoclonal or polyclonal forms. Validation includes testing for cross-reactivity with other ARP family members. Proper controls, like siRNA knockdowns, ensure specificity. Commercial antibodies often cite applications in human, mouse, or rat models, aiding comparative studies across species. Overall, ACTR1A antibodies are vital for dissecting cytoskeletal mechanisms and their pathological implications.