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ACOT11抗体

Rabbit Polyclonal ACOT11 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-13

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
ACOT11抗体
英文名称：
Rabbit Polyclonal ACOT11 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3723 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
ACOT11

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesBFIT; THEA; THEM1; STARD14
WB Predicted band size68 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human ACOT11
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human liver cancer tissue, Human fetal kidney tissue, Primary antibody: P07750(ACOT11 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07750(ACOT11 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07750(ACOT11 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于ACOT11抗体的3-4篇文献示例(注：以下信息为模拟虚构，仅供参考)：

1. **文献名称**: *ACOT11 regulates lipid metabolism and promotes hepatocellular carcinoma progression*

**作者**: Zhang Y, et al. (2020)

**摘要**: 本研究利用ACOT11特异性抗体，发现ACOT11在肝癌组织中显著高表达，并通过调控脂肪酸氧化促进肿瘤生长，提示其作为肝癌治疗潜在靶点。

2. **文献名称**: *Characterization of ACOT11 enzyme activity and antibody validation in metabolic syndrome models*

**作者**: Smith JL, et al. (2018)

**摘要**: 通过开发并验证ACOT11多克隆抗体，证实ACOT11在肥胖小鼠肝脏中表达上调，其硫酯酶活性与胰岛素抵抗相关。

3. **文献名称**: *ACOT11 deficiency alters cellular lipid composition and inflammatory responses*

**作者**: Brown KR, et al. (2021)

**摘要**: 使用ACOT11敲除小鼠模型及特异性抗体，证明ACOT11缺失导致巨噬细胞脂质累积异常，并增强促炎因子分泌。

4. **文献名称**: *Proteomic analysis of ACOT11 interaction network in adipocytes*

**作者**: Lee S, et al. (2019)

**摘要**: 通过免疫共沉淀(Co-IP)结合ACOT11抗体，揭示其在脂肪细胞中与PPARγ等代谢调控蛋白相互作用，影响脂滴形成。

(注：实际文献需通过PubMed、Google Scholar等平台检索关键词“ACOT11 antibody”或“acyl-CoA thioesterase 11”获取。)

       

背景信息

The ACOT11 (Acyl-CoA Thioesterase 11) antibody is a tool used to study the function and expression of the ACOT11 enzyme, which belongs to the acyl-CoA thioesterase family. ACOT11 catalyzes the hydrolysis of acyl-CoA thioesters to free fatty acids and coenzyme A, regulating lipid metabolism and cellular energy homeostasis. It is implicated in diverse biological processes, including fatty acid oxidation, lipid signaling, and inflammation.

ACOT11 is localized in mitochondria and peroxisomes, with tissue-specific expression patterns, notably high in the liver, kidney, and brain. Research suggests its involvement in metabolic disorders, neurodegenerative diseases, and cancer. For instance, ACOT11 overexpression has been linked to altered lipid profiles in hepatocellular carcinoma, while its downregulation may influence neuroinflammation in Alzheimer’s disease.

The ACOT11 antibody enables detection and quantification of the protein via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in exploring ACOT11’s role in lipid metabolism pathways, its interaction with other enzymes (e.g., ACSL), and its potential as a therapeutic target. Recent studies also highlight its regulatory effects on PPARα signaling, linking it to adaptive responses during fasting or stress. Continued research with this antibody may uncover novel mechanisms in metabolic syndrome and cancer progression.

       
ACOT11抗体;ACOT11;ACOT11 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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