ACOT7抗体

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P07749(ACOT7 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The ACOT7 (Acyl-CoA Thioesterase 7) antibody is a tool used to study the ACOT7 enzyme, a member of the acyl-CoA thioesterase family. ACOT7 catalyzes the hydrolysis of acyl-CoA thioesters to free fatty acids and CoA, regulating lipid metabolism and cellular signaling. It is highly expressed in the brain, liver, and immune cells, playing roles in energy homeostasis, inflammation, and neuroprotection. Dysregulation of ACOT7 is implicated in metabolic disorders, neurodegenerative diseases (e.g., Alzheimer’s), and cancer, making it a focus of therapeutic research.

ACOT7 antibodies are essential for detecting protein expression, localization, and post-translational modifications via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate ACOT7’s interactions with metabolic pathways (e.g., β-oxidation, lipid synthesis) and its impact on cellular processes like apoptosis and oxidative stress. Recent studies highlight ACOT7’s role in modulating mitochondrial function and inflammatory responses, linking it to insulin resistance and neuronal survival. Validated antibodies are critical for distinguishing ACOT7 isoforms and ensuring specificity in experimental models, including knockout controls. Ongoing research aims to clarify its dual roles in health and disease, positioning ACOT7 as a potential biomarker or drug target.