ALKBH2抗体 新品

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human fetal liver tissue, Human seminoma tissue, RAW264.7 cells, Primary antibody: P07735(ALKBH2 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

The ALKBH2 antibody is a crucial tool in studying the AlkB homolog 2 protein, a member of the AlkB family of dioxygenases involved in DNA repair. ALKBH2 specifically repairs alkylation damage, such as 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions, through oxidative demethylation. This enzyme plays a vital role in maintaining genomic stability by counteracting mutagenic or cytotoxic effects of alkylating agents, making it relevant to cancer research, neurodegenerative diseases, and environmental toxicology. Dysregulation of ALKBH2 has been linked to tumorigenesis, as its repair activity may influence cancer susceptibility and therapeutic responses.

The ALKBH2 antibody enables the detection, localization, and quantification of the protein in various experimental settings, including Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Researchers utilize it to investigate ALKBH2's expression patterns across tissues, its subcellular distribution (primarily nuclear), and its modulation under DNA-damaging conditions. Commercial ALKBH2 antibodies are typically raised against specific epitopes, with validation in knockout cell lines or siRNA-treated samples to confirm specificity. Some antibodies distinguish between post-translational modifications or conformational states. Applications extend to clinical studies exploring ALKBH2 as a potential biomarker for cancer prognosis or as a target for chemotherapy adjuvants. Recent studies also examine its non-canonical roles in epigenetics and RNA modification, expanding the utility of ALKBH2 antibodies in interdisciplinary research.