ABCG4抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P07733(ABCG4 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

The ABCG4 antibody is a research tool designed to detect and study the ATP-binding cassette sub-family G member 4 (ABCG4), a transmembrane protein involved in lipid transport and cellular homeostasis. ABCG4 belongs to the ABC transporter superfamily, which plays critical roles in ATP-dependent transport of various substrates, including cholesterol, sterols, and lipids. It shares structural and functional similarities with ABCG1. another family member implicated in macrophage cholesterol efflux and reverse cholesterol transport, a process linked to atherosclerosis prevention.

ABCG4 is predominantly expressed in tissues such as the liver, brain, and endothelial cells, where it regulates lipid distribution and cellular detoxification. Research suggests its involvement in maintaining lipid homeostasis in the central nervous system and modulating drug resistance in cancer cells by exporting chemotherapeutic agents. Antibodies targeting ABCG4 enable researchers to investigate its expression patterns, subcellular localization, and interactions in disease models, particularly in neurodegenerative disorders, metabolic syndromes, and oncology.

Current studies focus on clarifying ABCG4's physiological roles, its partnership with ABCG1 in lipid metabolism, and its potential as a therapeutic target. The development of specific ABCG4 antibodies has been pivotal in advancing these studies, offering insights into its mechanism and relevance in health and disease.