ABCB6抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate, Primary antibody: P07728(ABCB6 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07728(ABCB6 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07728(ABCB6 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

**Background of ABCB6 Antibody**

The ABCB6 antibody is a research tool targeting the ATP-binding cassette subfamily B member 6 (ABCB6) protein, a transporter within the ATP-binding cassette (ABC) superfamily. ABCB6 is implicated in multiple cellular processes, including porphyrin transport, heme biosynthesis, and mitochondrial function. It localizes to both the outer mitochondrial membrane and lysosomal membranes, suggesting roles in intracellular organelle communication and iron metabolism.

ABCB6 antibodies are widely used to study protein expression, localization, and function in various tissues and disease models. Dysregulation of ABCB6 has been linked to disorders such as iron-overload syndromes, chemotherapy resistance in cancers, and the rare genetic disorder dyschromatosis universalis hereditaria (DUH). Research utilizing these antibodies has revealed ABCB6's potential as a biomarker in cancer prognosis and its involvement in cellular detoxification pathways.

Antibody specificity is critical, as ABCB6 shares structural homology with other ABC transporters. Validation via knockout controls or siRNA-mediated silencing is often required. Commercial ABCB6 antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or cytoplasmic domains). Applications include Western blotting, immunohistochemistry, and immunofluorescence, aiding in elucidating ABCB6's role in health and disease. Ongoing studies focus on its therapeutic potential in modulating drug resistance and metabolic disorders.