AASDHPPT抗体 新品

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: P07727(AASDHPPT Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07727(AASDHPPT Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P07727(AASDHPPT Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The AASDHPPT (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase) antibody is a tool used to study the AASDHPPT protein, a key enzyme encoded by the AASDHPPT gene in humans. This protein belongs to the phosphopantetheinyl transferase (PPPT) family and plays a dual role in cellular metabolism. It facilitates the synthesis of coenzyme A (CoA), a critical cofactor in fatty acid metabolism and the tricarboxylic acid (TCA) cycle, by transferring phosphopantetheine groups to carrier proteins. Additionally, it participates in the α-aminoadipic acid pathway, which is involved in lysine degradation and the biosynthesis of secondary metabolites.

The AASDHPPT antibody is typically developed in animal hosts (e.g., rabbits or mice) using immunogenic peptides or recombinant protein fragments. It enables researchers to detect AASDHPPT expression levels, localization, and interactions in various tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Dysregulation of AASDHPPT has been linked to metabolic disorders, neurodegenerative diseases, and cancer, making this antibody valuable for exploring disease mechanisms.

Studies utilizing this antibody have contributed to understanding CoA biosynthesis regulation and mitochondrial function. Its specificity is often validated through knockout (KO) controls or siRNA-mediated protein depletion. Researchers also employ it to investigate AASDHPPT's role in cellular stress responses and metabolic reprogramming, particularly in contexts like tumor progression or metabolic syndrome.