VANGL1抗体 新品

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human lymphoma tissue, Human testis tissue, Primary antibody: P07721(VANGL1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07721(VANGL1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07721(VANGL1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The VANGL1 antibody is a crucial tool in studying the VANGL1 protein, encoded by the VANGL1 gene, which plays a pivotal role in the Planar Cell Polarity (PCP) pathway. This evolutionarily conserved pathway regulates tissue organization and polarized cell behaviors during embryonic development, such as neural tube closure, cochlear hair cell alignment, and directional cell migration. VANGL1. a transmembrane protein, interacts with other PCP components like Frizzled and Dishevelled to coordinate cell polarity and tissue morphogenesis. Dysregulation of VANGL1 is linked to congenital defects (e.g., neural tube defects) and diseases like cancer.

The VANGL1 antibody enables researchers to detect, localize, and quantify VANGL1 expression in cells and tissues via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It is widely used to investigate VANGL1's functional mechanisms, interactions with signaling partners, and its role in developmental disorders or cancer progression. Specificity and validation (e.g., knockout controls) are critical to ensure reliable results.

Recent studies highlight VANGL1's potential as a therapeutic target or biomarker, particularly in cancers with aberrant PCP signaling. The antibody thus serves as a key reagent for unraveling VANGL1's contributions to cellular processes and disease pathogenesis.