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TYR抗体

Rabbit Polyclonal TYR Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-13

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
TYR抗体
英文名称：
Rabbit Polyclonal TYR Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3686 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
TYR

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCMM8; OCA1A; OCAIA; SHEP3
WB Predicted band size60 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human TYR
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane 1-3: A375 cells, Hela cells, Jurkat cells, Primary antibody: P07698(TYR Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07698(TYR Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07698(TYR Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于TYR(酪氨酸酶)抗体的参考文献示例(文献为虚拟构造，仅作格式参考)：

1. **文献名称**: "Monoclonal Antibodies Targeting Tyrosinase for Melanoma Immunodetection"

**作者**: Smith J, et al.

**摘要**: 该研究开发了一种高特异性抗TYR单克隆抗体，用于黑色素瘤的免疫组化检测。实验表明，该抗体在转移性黑色素瘤组织中表现出高敏感性和特异性，可作为临床病理诊断的潜在工具。

2. **文献名称**: "Autoantibodies Against Tyrosinase in Vitiligo Pathogenesis"

**作者**: Lee H, et al.

**摘要**: 通过ELISA和蛋白质印迹分析，研究发现白癜风患者血清中TYR自身抗体水平显著升高，提示TYR自身免疫反应可能在色素脱失机制中起关键作用，为靶向治疗提供了新方向。

3. **文献名称**: "TYR Antibody-Based Therapeutic Nanoparticles for Melanoma Treatment"

**作者**: Zhang R, et al.

**摘要**: 研究构建了负载化疗药物的TYR抗体偶联纳米颗粒，可特异性靶向黑色素瘤细胞。体内实验显示显著抑制肿瘤生长，且对正常组织毒性较低，展示了TYR抗体在靶向治疗中的应用潜力。

4. **文献名称**: "Comparative Analysis of TYR Antibody Performance in Immunohistochemistry"

**作者**: Garcia M, et al.

**摘要**: 对比了四种商用TYR抗体在不同组织样本中的染色效果，发现克隆TY99在福尔马林固定石蜡包埋组织中稳定性最佳，为病理诊断中抗体选择提供了实用指南。

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**注**：以上文献为示例，实际研究中请通过PubMed、Web of Science或Google Scholar等平台检索真实文献。建议使用关键词“tyrosinase antibody melanoma”、“tyrosinase autoantibody vitiligo”等进行筛选。

       

背景信息

TYR (Tyrosinase) antibodies are immunological tools targeting tyrosinase, a key enzyme in melanin synthesis. Found in melanocytes and melanoma cells, tyrosinase catalyzes tyrosine oxidation to produce melanin pigments, critical for skin, hair, and eye pigmentation. Its dysregulation is linked to pigmentary disorders (e.g., albinism, vitiligo) and melanoma progression. TYR antibodies are widely used in research to study melanocyte biology, tumorigenesis, and drug responses. Clinically, they serve as diagnostic markers for melanoma in immunohistochemistry (IHC) and ELISA, aiding in tumor identification and monitoring.

Monoclonal TYR antibodies offer high specificity for detecting tyrosinase in tissue samples, while polyclonal variants enhance sensitivity in diverse experimental settings. Therapeutic applications are emerging, including antibody-based therapies and CAR-T cells targeting tyrosinase-expressing melanoma. However, challenges persist, such as cross-reactivity with similar epitopes in normal tissues, potentially causing off-target effects.

Recent advances focus on engineering humanized antibodies to improve safety and efficacy. TYR antibodies also contribute to understanding autoimmune responses in vitiligo, where autoantibodies against tyrosinase may drive melanocyte destruction. Overall, TYR antibodies bridge basic research and clinical innovation, holding promise for both diagnostic precision and therapeutic breakthroughs in oncology and dermatology.

       
TYR抗体;TYR;TYR Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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