TRPV4抗体

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P07689(TRPV4 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07689(TRPV4 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The TRPV4 (Transient Receptor Potential Vanilloid 4) antibody is a key tool for studying the TRPV4 ion channel, a member of the TRP superfamily involved in diverse physiological and pathological processes. TRPV4 functions as a calcium-permeable cation channel activated by mechanical stimuli, temperature, osmotic changes, and lipid mediators. It plays critical roles in osmoregulation, thermosensation, mechanotransduction, and pain signaling, with implications in bone development, neuropathies, cardiovascular function, and inflammatory responses. Dysregulation of TRPV4 is linked to skeletal dysplasia, neurodegenerative diseases, edema, and chronic pain syndromes.

TRPV4 antibodies are widely used to detect protein expression, localization, and modulation in tissues and cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Their specificity is validated using knockout models or blocking peptides to ensure accurate detection, as TRPV4 shares structural homology with other TRP channels. These antibodies help elucidate TRPV4's complex regulation, including splice variants, post-translational modifications, and tissue-specific interactions.

Research leveraging TRPV4 antibodies has advanced understanding of its role in disease mechanisms and therapeutic targeting. For instance, studies explore TRPV4 inhibitors for treating pulmonary edema, osteoarthritis, and neuropathic pain. However, challenges remain in developing isoform-selective antibodies due to TRPV4's structural diversity. Overall, TRPV4 antibodies are indispensable for dissecting the channel's multifunctional biology and translational potential in precision medicine.