TPM1抗体

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     Gel: 12%SDS-PAGE, Lysate: 50 μg, Lane: Mouse heart tissue, Primary antibody: P07687(TPM1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07687(TPM1 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07687(TPM1 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

TPM1 (Tropomyosin 1) antibodies are tools used to study the expression and function of TPM1. a key protein in the tropomyosin family. Tropomyosins are actin-binding proteins that regulate cytoskeletal dynamics and muscle contraction by stabilizing actin filaments and modulating their interaction with myosin. The TPM1 gene undergoes alternative splicing, producing multiple isoforms with distinct roles in different cell types. For example, high-molecular-weight isoforms (e.g., TPM1α/β) are critical in muscle cells, while low-molecular-weight isoforms are involved in non-muscle cellular processes like cell motility and division.

TPM1 antibodies are widely used in research to investigate tissue-specific expression, subcellular localization, and post-translational modifications of TPM1. They are essential in studying pathologies linked to TPM1 dysregulation, such as cancer (e.g., breast, gastric, and prostate cancers), where TPM1 often acts as a tumor suppressor. Loss of TPM1 expression is associated with increased metastasis and poor prognosis. Additionally, TPM1 mutations are implicated in inherited cardiomyopathies, making these antibodies valuable in cardiovascular research.

These antibodies are typically validated via Western blotting, immunohistochemistry, or immunofluorescence. Researchers must select isoform-specific antibodies due to the high homology among tropomyosin family members. Understanding TPM1's role in cellular mechanics and disease mechanisms continues to drive the development and application of TPM1 antibodies in both basic and translational studies.