TRAF3IP1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human brain malignant glioma tissue, Primary antibody: P07675(TRAF3IP1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07675(TRAF3IP1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P07675(TRAF3IP1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The TRAF3IP1 (TRAF3-interacting protein 1) antibody is a research tool used to detect and study the TRAF3IP1 protein, a cytoplasmic adaptor protein involved in immune signaling pathways. TRAF3IP1. also known as INAP or Act1. interacts with TRAF3 (TNF receptor-associated factor 3) and other signaling molecules, playing a role in regulating NF-κB and MAPK pathways. It is critical for signal transduction mediated by cytokines like IL-17. linking receptor activation to downstream inflammatory responses. Dysregulation of TRAF3IP1 has been implicated in autoimmune diseases, cancer, and chronic inflammatory conditions.

The antibody is widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate TRAF3IP1 expression, localization, and interactions. Researchers utilize it to explore its role in immune cell activation, cytokine production, and disease mechanisms. Commercially available TRAF3IP1 antibodies are typically raised in hosts like rabbits or mice, validated for specificity using knockout controls or siRNA knockdown. Applications may extend to studying TRAF3IP1’s involvement in B-cell development, Th17-mediated inflammation, or its regulatory effects on TRAF3-dependent antiviral responses. Proper validation ensures reliable detection of the ~60 kDa protein across human, mouse, or rat samples, aiding mechanistic studies in both physiological and pathological contexts.