PLAAT4抗体 新品

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07662(PLAAT4 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

**Background of PLAAT4 Antibody**

The PLAAT4 (phospholipase A and acyltransferase 4) antibody is a tool used to detect and study the PLAAT4 protein, a member of the phospholipase A/acyltransferase (PLAAT) family. PLAAT4. also known as HRASLS4 or H-rev107. is encoded by the *PLAAT4* gene and is involved in lipid metabolism, membrane remodeling, and cellular signaling. It exhibits phospholipase A1/A2 activity, catalyzing the hydrolysis of phospholipids, and participates in the production of signaling lipids like N-acylphosphatidylethanolamines (NAPEs), precursors to bioactive endocannabinoids.

PLAAT4 is implicated in tumor suppression, inflammation, and apoptosis. Studies highlight its role in cancer progression, where it often acts as a tumor suppressor by inducing cell cycle arrest, apoptosis, or autophagy in various cancer models. Dysregulation of PLAAT4 expression is linked to malignancies, neurodegenerative diseases, and metabolic disorders.

The PLAAT4 antibody enables researchers to investigate its expression patterns, subcellular localization (e.g., endoplasmic reticulum, lipid droplets), and interactions in both normal and pathological conditions. It is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Understanding PLAAT4's functions through antibody-based research may reveal therapeutic targets for diseases associated with lipid dysregulation or aberrant cell survival pathways.