TEKT3抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07661(TEKT3 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07661(TEKT3 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The TEKT3 antibody is a tool used to study tektin-3. a member of the tektin family of cytoskeletal proteins. Tektins are evolutionarily conserved, filament-forming proteins critical for the structural integrity and function of cilia, flagella, and centrioles. TEKT3. specifically, is prominently expressed in tissues with motile cilia or flagella, such as sperm cells, respiratory epithelium, and fallopian tubes. It plays a vital role in maintaining the stability and proper assembly of axonemal microtubules, which are essential for cell motility and signaling.

Research on TEKT3 has focused on its involvement in male infertility, as mutations or dysregulation are linked to sperm flagellar defects, impairing motility and fertilization capacity. TEKT3 antibodies enable detection and localization of the protein in cells and tissues, aiding studies on ciliopathies (e.g., primary ciliary dyskinesia) and reproductive disorders. These antibodies are commonly used in techniques like immunofluorescence, Western blotting, and immunohistochemistry to assess expression patterns, protein interactions, and functional roles in developmental and pathological contexts.

Commercial TEKT3 antibodies are typically raised in rabbits or mice using peptide antigens, with validation in specific applications. Their utility extends to both basic research and clinical diagnostics, offering insights into ciliary biology and potential therapeutic targets for related diseases.