SOX7抗体

**Background of SOX7 Antibody**

SOX7. a member of the SOX (Sry-related HMG box) family of transcription factors, plays critical roles in embryonic development, cell differentiation, and tissue homeostasis. It binds to DNA through its conserved HMG domain, regulating target genes involved in organogenesis, cardiovascular development, and stem cell maintenance. SOX7 is also implicated in cancer biology, where it often acts as a tumor suppressor by inhibiting Wnt/β-catenin signaling and suppressing epithelial-mesenchymal transition (EMT).

SOX7 antibodies are essential tools for studying the expression, localization, and function of the SOX7 protein in various biological contexts. These antibodies are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect SOX7 in tissue sections, cell lines, or experimental models. Given the high homology among SOX family members, SOX7 antibodies must exhibit high specificity to avoid cross-reactivity with related proteins like SOX17 or SOX18. Validation often includes knockout controls or siRNA-mediated knockdown to confirm target specificity.

Research utilizing SOX7 antibodies has expanded insights into developmental disorders, cancer progression, and regenerative mechanisms. Dysregulation of SOX7 is linked to conditions such as colorectal cancer, lung adenocarcinoma, and congenital heart defects, underscoring its clinical relevance. Reliable SOX7 antibodies thus serve as vital reagents for both basic research and translational studies.