SOCS5抗体

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07609(SOCS5 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07609(SOCS5 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The SOCS5 (Suppressor of Cytokine Signaling 5) antibody is a research tool used to study the SOCS5 protein, a member of the SOCS family comprising eight intracellular proteins (SOCS1–7 and CIS). These proteins regulate cytokine signaling by inhibiting the JAK-STAT pathway through direct binding to JAK kinases, cytokine receptors, or signaling complexes, often promoting ubiquitination and degradation of targets. SOCS5 is known to modulate immune responses, cancer progression, and viral infections. It suppresses signaling by interleukins (e.g., IL-4. IL-6) and growth factors, influencing T-helper cell differentiation and tumorigenesis. In cancer, SOCS5 may act as a tumor suppressor by inhibiting EGFR and VEGF pathways, thereby reducing cell proliferation and metastasis. Additionally, it plays roles in viral defense, such as inhibiting hepatitis C virus entry.

The SOCS5 antibody enables detection and functional analysis of SOCS5 in various experimental settings (e.g., Western blot, immunohistochemistry, flow cytometry), aiding investigations into its expression patterns, interactions, and mechanisms in health and disease. Studies using this antibody have highlighted its potential as a therapeutic target or biomarker in inflammatory disorders, cancers, and infections. However, the precise molecular pathways and context-dependent roles of SOCS5 remain under exploration, necessitating further research to clarify its regulatory networks and clinical relevance.