NAPA抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, Jurkat cells, human liver cancer tissue, mouse brain tissue, Primary antibody: P07605(NAPA Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07605(NAPA Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07605(NAPA Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

NAPA (NSF Attachment Protein Alpha), also known as α-SNAP, is a critical component of intracellular vesicle trafficking and membrane fusion processes. It belongs to the SNAP family of soluble proteins that interact with the SNARE (Soluble NSF Attachment Protein Receptor) complex, which mediates the fusion of transport vesicles with target membranes. NAPA binds to the SNARE complex and recruits NSF (N-ethylmaleimide-sensitive fusion protein), an ATPase essential for disassembling SNAREs after fusion, thereby recycling them for subsequent rounds of membrane docking. This mechanism is vital for neurotransmitter release, organelle biogenesis, and protein secretion.

Antibodies targeting NAPA are widely used in biomedical research to study vesicular transport dynamics, synaptic function, and cellular secretion pathways. They enable the detection, localization, and quantification of NAPA in various experimental models, including immunoprecipitation, Western blotting, and immunofluorescence microscopy. Dysregulation of NAPA has been implicated in neurological disorders, such as epilepsy and neurodegenerative diseases, as well as in cancer progression due to its role in regulating cell proliferation and apoptosis. Research utilizing NAPA antibodies has provided insights into pathological mechanisms and potential therapeutic targets. These antibodies thus serve as essential tools for elucidating the molecular basis of vesicle trafficking and its implications in health and disease.