ZEB2抗体

The ZEB2 antibody is a crucial tool for detecting Zinc Finger E-Box Binding Homeobox 2 (ZEB2), a transcription factor involved in epithelial-mesenchymal transition (EMT), embryonic development, and cellular differentiation. ZEB2. part of the ZEB family, binds DNA via zinc finger domains to regulate target genes, often repressing epithelial markers (e.g., E-cadherin) and promoting mesenchymal traits. Dysregulation of ZEB2 is linked to cancer metastasis, fibrosis, and neurodevelopmental disorders like Mowat-Wilson syndrome (caused by ZEB2 mutations). Researchers use ZEB2 antibodies in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to study its expression, localization, and DNA-binding activity. These antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions) to ensure specificity. Commercial ZEB2 antibodies are validated for cross-reactivity and performance across species (human, mouse, rat). Their applications span cancer biology (tumor progression studies), developmental biology (neural crest cell differentiation), and disease mechanism research. Reliable ZEB2 detection aids in understanding its role in TGF-β signaling, stem cell plasticity, and therapeutic resistance, making the antibody essential for both basic and translational studies.