PRDX5抗体

The PRDX5 antibody is a crucial tool for studying peroxiredoxin-5 (PRDX5), a member of the peroxiredoxin family of antioxidant enzymes. PRDX5 plays a vital role in cellular redox homeostasis by scavenging reactive oxygen species (ROS) and protecting cells from oxidative damage. Unlike other peroxiredoxins, PRDX5 exhibits a unique subcellular distribution, localized in mitochondria, cytoplasm, nucleus, and peroxisomes, enabling its involvement in diverse physiological processes, including apoptosis, inflammation, and signal transduction. PRDX5 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression levels, tissue localization, and dynamic changes under oxidative stress conditions. These antibodies aid in exploring PRDX5's dual role as both a cytoprotective agent and a modulator in diseases such as neurodegenerative disorders, cancer, and diabetes. Researchers also utilize PRDX5 antibodies to investigate post-translational modifications (e.g., phosphorylation) that regulate its enzymatic activity. Commercially available PRDX5 antibodies are typically raised against recombinant protein or peptide antigens, with specificity validated through knockout controls. Their cross-reactivity varies across species, commonly including human, mouse, and rat samples. As oxidative stress mechanisms gain prominence in therapeutic research, PRDX5 antibodies remain essential for elucidating disease pathways and evaluating potential biomarkers or drug targets.