PIWIL1抗体

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07544(PIWIL1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P07544(PIWIL1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

PIWIL1 (P-element-induced wimpy testis-like 1), also known as Hiwi, is a member of the PIWI protein family, which plays critical roles in germline development, stem cell maintenance, and RNA interference pathways. It is predominantly expressed in germ cells and some somatic stem cells, where it interacts with piRNAs (PIWI-interacting RNAs) to regulate transposon silencing, genome stability, and epigenetic programming. Dysregulation of PIWIL1 has been implicated in various cancers, including germ cell tumors, gliomas, and gastrointestinal cancers, where its abnormal expression often correlates with poor prognosis and tumorigenesis.

PIWIL1 antibodies are essential tools for studying its biological functions and pathological roles. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to detect PIWIL1 expression patterns in tissues, stem cells, or cancer samples. Specificity and validation are critical, as PIWI family members share structural homology, requiring antibodies to distinguish PIWIL1 from paralogs like PIWIL2-4. Researchers also utilize PIWIL1 antibodies to explore its interactions with piRNAs or other proteins, aiding in mechanistic studies of germ cell development, stem cell self-renewal, and cancer progression. Despite challenges like cross-reactivity and limited expression in normal somatic tissues, these antibodies remain pivotal in advancing reproductive biology, oncology, and regenerative medicine research.