PGC抗体

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     Gel: 12%SDS-PAGE, Lysate: 50 μg, Lane: 823 cells, Primary antibody: P07538(PGC Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P07538(PGC Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07538(PGC Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

PGC (Peroxisome Proliferator-Activated Receptor Gamma Coactivator) antibodies are essential tools for studying the PGC family of transcriptional coactivators, primarily PGC-1α, PGC-1β, and PRC. These proteins play pivotal roles in regulating mitochondrial biogenesis, energy metabolism, and adaptive thermogenesis by interacting with nuclear receptors and transcription factors. PGC-1α, the most studied member, is a master regulator of cellular energy homeostasis, influencing oxidative phosphorylation, gluconeogenesis, and fatty acid oxidation. Dysregulation of PGC-1α is linked to metabolic disorders (e.g., diabetes, obesity), neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s), and cancer.

PGC antibodies enable detection and quantification of these proteins in various experimental models, including Western blotting, immunohistochemistry, and immunofluorescence. They are critical for investigating tissue-specific expression patterns, such as high PGC-1α levels in metabolically active tissues (muscle, liver, brown adipose) or its suppression in pathological conditions. Researchers also use these antibodies to explore therapeutic interventions targeting mitochondrial dysfunction or metabolic syndromes.

Commercially available PGC antibodies are typically developed in rabbits or mice, with validation via knockout controls to ensure specificity. Challenges include cross-reactivity due to homologous domains among PGC family members, necessitating careful antibody selection. Recent studies emphasize PGC-1α’s role in aging and exercise-induced metabolic adaptation, underscoring the antibody’s relevance in translational research. Overall, PGC antibodies remain indispensable for dissecting molecular pathways governing energy metabolism and disease mechanisms.