PAK2抗体

The p21-activated kinase 2 (PAK2) antibody is a key tool for studying the role of PAK2. a serine/threonine kinase belonging to the PAK family, which is activated by binding to Rho GTPases like Rac and Cdc42. PAK2 regulates diverse cellular processes, including cytoskeletal dynamics, cell motility, survival, and apoptosis. Unlike PAK1. which is primarily linked to growth signaling, PAK2 has dual roles in pro-survival and pro-apoptotic pathways depending on cellular context. It is activated via autophosphorylation upon GTPase binding or proteolytic cleavage by caspases during apoptosis, generating a constitutively active fragment that promotes cell death. PAK2 dysregulation is implicated in cancer, neurological disorders, and immune diseases, with its overexpression observed in tumors and its knockout models showing developmental defects. PAK2 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect PAK2 expression, phosphorylation status, and subcellular localization. Specificity is critical, as PAK isoforms share structural homology; high-quality antibodies distinguish PAK2 from PAK1/3 and recognize both full-length (~58-62 kDa) and cleaved (~34 kDa) forms. These antibodies aid in exploring PAK2's context-dependent functions, therapeutic targeting, and its interplay with signaling pathways like MAPK and PI3K/AKT.