DNAJC3抗体

DNAJC3. also known as P58^IPK or ERdj6. is a member of the Hsp40/DnaJ protein family that functions as a co-chaperone in the endoplasmic reticulum (ER). It plays a critical role in the unfolded protein response (UPR) by interacting with the ER-resident chaperone BiP/GRP78. aiding in protein folding, quality control, and stress adaptation. DNAJC3 antibodies are immunological tools designed to detect and study this protein's expression, localization, and interactions in cellular models. These antibodies are widely used in research to investigate ER stress mechanisms linked to diseases such as diabetes, neurodegenerative disorders, and cancer, where dysregulated protein homeostasis contributes to pathogenesis. Mutations in the DNAJC3 gene are associated with rare genetic conditions like early-onset diabetes and multisystemic neurodegeneration, making its study clinically relevant. Antibodies against DNAJC3 enable visualization of its stress-induced upregulation and help delineate its role in mitigating proteotoxic stress. Additionally, they assist in exploring potential therapeutic strategies targeting UPR pathways. Validation of DNAJC3 antibodies typically involves techniques like Western blotting, immunofluorescence, and immunohistochemistry, ensuring specificity for research reproducibility. Their application extends to both in vitro and in vivo models, providing insights into cellular stress responses and disease mechanisms.