NR4A2抗体

The NR4A2 antibody is a research tool designed to detect and study the nuclear receptor subfamily 4 group A member 2 (NR4A2), a transcription factor also known as Nurr1 or NOT. NR4A2 is a ligand-independent orphan receptor belonging to the steroid/thyroid hormone receptor superfamily. It plays critical roles in regulating gene expression involved in dopamine neuron development, inflammatory responses, and cellular proliferation/apoptosis. Dysregulation of NR4A2 is linked to neurological disorders, including Parkinson’s disease, schizophrenia, and depression, as well as cancers and metabolic syndromes. The antibody enables the identification and localization of NR4A2 in cells and tissues through techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Researchers use it to investigate NR4A2’s expression patterns, interactions with co-regulators, and its role in disease mechanisms. Available as monoclonal or polyclonal versions from various hosts (e.g., rabbit, mouse), the antibody’s specificity and affinity are validated for experimental reproducibility. Its applications extend to drug development, biomarker discovery, and understanding NR4A2’s dual role as a tumor suppressor or oncogene, depending on cellular context.