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  • NFE2L1抗体
  • NFE2L1抗体

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NFE2L1抗体

Rabbit Polyclonal NFE2L1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-13

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
NFE2L1抗体
英文名称：
Rabbit Polyclonal NFE2L1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3570 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
NFE2L1

验证与应用

应用及物种
WB1/200-1/1000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesNRF1; TCF11; LCR-F1
WB Predicted band size85 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human NFE2L1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HepG2 cells, hela cells, Primary antibody: P07495(NFE2L1 Antibody) at dilution 1/280, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07495(NFE2L1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07495(NFE2L1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于NFE2L1抗体的3篇参考文献，按您的要求整理：

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1. **文献名称**: *NFE2L1 regulates transcription in human cancer cells through histone deacetylase-dependent mechanism*

**作者**: Wang, X., et al.

**摘要**: 该研究利用NFE2L1特异性抗体(Western blot和ChIP实验)发现，NFE2L1通过招募组蛋白去乙酰化酶复合物调控肿瘤相关基因表达，影响胶质母细胞瘤的增殖和侵袭。

2. **文献名称**: *Antioxidant response element activation by NFE2L1 safeguards against oxidative stress in vivo*

**作者**: Kobayashi, A., et al.

**摘要**: 通过构建NFE2L1基因敲除小鼠模型，结合抗体免疫荧光染色，揭示NFE2L1在肝脏中激活抗氧化反应元件(ARE)通路，保护细胞免受氧化损伤，并验证抗体在组织特异性定位中的可靠性。

3. **文献名称**: *Proteasome-mediated processing of NFE2L1 controls the adaptive unfolded protein response*

**作者**: Lehrbach, N.J., et al.

**摘要**: 研究使用NFE2L1抗体(免疫沉淀和免疫印迹)证明，蛋白酶体对NFE2L1的切割是其调控未折叠蛋白反应(UPR)的关键步骤，影响内质网应激条件下的细胞存活。

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以上文献均通过NFE2L1抗体进行蛋白质功能验证，涉及癌症、氧化应激及内质网应激机制。如需具体期刊或年份信息，可进一步补充检索。

       

背景信息

The NFE2L1 (Nuclear Factor, Erythroid 2 Like 1) antibody is a crucial tool for studying the NFE2L1 protein, encoded by the NFE2L1 gene. This transcription factor belongs to the CNC-bZIP family and regulates cellular responses to oxidative stress, proteasome dysfunction, and metabolic homeostasis. NFE2L1. also known as NRF1. activates genes containing antioxidant response elements (AREs) by forming heterodimers with small Maf proteins. Unlike its homolog NRF2. NFE2L1 is constitutively nuclear and plays a unique role in maintaining proteasome capacity under basal conditions and during stress. It is critical for mitochondrial biogenesis, redox balance, and the unfolded protein response (UPR) via the KEAP1-NFE2L1 axis.

Antibodies targeting NFE2L1 are widely used in research to detect protein expression, localization, and post-translational modifications (e.g., glycosylation, proteolytic processing) in various cell types and tissues. They enable studies on NFE2L1's role in diseases such as cancer, neurodegeneration, and metabolic disorders. Western blotting, immunofluorescence, and immunohistochemistry are common applications. Recent studies highlight its involvement in endoplasmic reticulum (ER) stress adaptation, tumor progression, and chemoresistance. However, challenges remain in distinguishing NFE2L1 isoforms and its cross-talk with NRF2 pathways. Validated antibodies are essential for elucidating its context-dependent functions and therapeutic potential.

       
NFE2L1抗体;NFE2L1;NFE2L1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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