MYOZ1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse skeletal muscle tissue lysate, Primary antibody: P07467(MYOZ1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 15 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07467(MYOZ1 Antibody) at dilution 1/140. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07467(MYOZ1 Antibody) at dilution 1/140. (Original magnification: ×200)    

  
  

MYOZ1 (Myozenin 1), also known as calsarcin-1. is a striated muscle-specific protein that localizes to the Z-disc of sarcomeres, playing a critical role in maintaining structural integrity and mediating signaling pathways in skeletal and cardiac muscle. It interacts with calcineurin, a calcium-dependent phosphatase, regulating muscle differentiation, hypertrophy, and stress response. MYOZ1 antibodies are immunological tools designed to detect and quantify MYOZ1 expression in research applications. These antibodies are widely used in studies investigating muscle physiology, disease mechanisms (e.g., cardiomyopathies, muscular dystrophies), and Z-disc-associated signaling networks.

Commercially available MYOZ1 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides corresponding to specific MYOZ1 epitopes. They are validated for techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP). Researchers utilize these antibodies to explore MYOZ1's role in muscle development, its interaction with proteins like α-actinin or telethonin, and its potential as a biomarker for muscle-related pathologies. Recent studies also highlight its involvement in regulating calcineurin/NFAT signaling, linking mechanical stress to transcriptional regulation.

Quality validation often includes testing on MYOZ1-expressing tissues (e.g., heart, skeletal muscle) and knockout controls to confirm specificity. MYOZ1 antibodies are essential for advancing understanding of muscle biology and disease pathways.