MCM7抗体

+ +

•  

   

     Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane: Jurkat cells, Primary antibody: P07445(MCM7 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P07445(MCM7 Antibody) at dilution 1/15. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07445(MCM7 Antibody) at dilution 1/15. (Original magnification: ×200)    

  
  

The MCM7 antibody targets minichromosome maintenance complex component 7 (MCM7), a critical protein involved in DNA replication initiation and cell cycle regulation. As part of the hexameric MCM2-7 helicase complex, MCM7 plays an essential role in unwinding DNA during replication, ensuring faithful genome duplication. Unlike other replication factors, MCM proteins are expressed exclusively during the cell cycle's G1 phase, making them reliable markers for cell proliferation.

MCM7 antibodies are widely used in research to study cell proliferation dynamics, particularly in cancer biology. Overexpression of MCM7 correlates with aggressive tumor behavior and poor prognosis, as rapidly dividing cancer cells require sustained DNA replication. These antibodies enable detection via techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence, helping distinguish proliferating cells from quiescent ones in tissues.

Clinically, MCM7 antibodies have diagnostic potential. For example, they aid in detecting cervical intraepithelial neoplasia when combined with p16INK4a staining. However, challenges persist in standardizing quantification methods and interpreting heterogeneous expression patterns across tumor types. Recent studies also explore MCM7's role in non-cancer contexts, such as viral replication interactions and stem cell dynamics. As a conserved replication licensing factor, MCM7 remains a focal point for understanding both normal cellular physiology and disease mechanisms.