MCM6抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-5: 293T cells, A549 cells, Raji cells, K562 cells, NIH/3T3 cells, Primary antibody: P07441(MCM6 Antibody) at dilution 1/433.3, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07441(MCM6 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07441(MCM6 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The MCM6 antibody is a crucial tool in molecular biology for studying the Minichromosome Maintenance Complex Component 6 (MCM6), a member of the MCM protein family. MCM proteins are essential for DNA replication, acting as part of the replication licensing complex that ensures DNA is copied only once per cell cycle, maintaining genomic stability. MCM6. along with MCM2-7. forms a hexameric helicase complex critical for initiating DNA replication by unwinding double-stranded DNA at replication origins.

MCM6 antibodies are widely used in research to detect MCM6 expression and localization, employing techniques like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies help investigate cell proliferation dynamics, as MCM6 is overexpressed in actively dividing cells, making it a biomarker for cellular proliferation. In cancer research, elevated MCM6 levels correlate with tumor aggressiveness and poor prognosis, highlighting its role in cancer diagnostics and therapeutic targeting.

Additionally, MCM6 antibodies aid in studying replication stress and cell cycle regulation, particularly during the G1/S phase transition. Dysregulation of MCM6 is linked to genomic instability and diseases like cancer. Commercial MCM6 antibodies are typically validated for specificity and sensitivity, ensuring reliable detection across experimental models. Their applications extend to understanding developmental biology, stem cell dynamics, and responses to DNA damage, cementing MCM6 as a pivotal focus in cellular and molecular research.