MCM10抗体

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P07439(MCM10 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

MCM10 antibodies are essential tools for studying the role of MCM10. a conserved eukaryotic protein critical for DNA replication. MCM10 is a component of the minichromosome maintenance (MCM) family, which regulates replication initiation and elongation. Unlike the MCM2-7 helicase complex, MCM10 does not directly unwind DNA but acts as a scaffolding protein, facilitating the assembly and stability of replication machinery. It interacts with MCM2-7. DNA polymerase α, and other replisome components, ensuring proper replication fork progression and genome integrity. MCM10 is vital during the G1/S phase transition and S phase, where it supports origin licensing and replication timing control.

Antibodies targeting MCM10 are widely used in research to investigate its expression, localization, and interactions. They enable techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP), helping to characterize MCM10's dynamic behavior during the cell cycle. Dysregulation of MCM10 is linked to replication stress, genomic instability, and diseases such as cancer, where its overexpression is observed in proliferating tumor cells. These antibodies also aid in exploring MCM10's potential as a biomarker for cell proliferation or therapeutic targeting. Researchers rely on high-specificity MCM10 antibodies to dissect its molecular mechanisms in replication fidelity and its broader implications in development and disease.