MAGED1抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: P07433(MAGED1 Antibody) at dilution 1/1200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07433(MAGED1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07433(MAGED1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

MAGED1 (Melanoma-associated antigen D1) is a member of the MAGE protein family, which shares a conserved MAGE homology domain. Initially identified in cancer-testis antigens, MAGE proteins are normally expressed in germ cells but re-emerge in various cancers, making them potential immunotherapy targets. MAGED1. encoded on the X chromosome, stands out for its broader physiological roles beyond oncology. It interacts with signaling pathways like p53. Wnt/β-catenin, and receptor tyrosine kinases, influencing cell proliferation, apoptosis, and differentiation. Studies link MAGED1 to neurodevelopment, placental function, and circadian rhythm regulation. It binds RTL1/RTL1AS in placental trophoblasts, impacting fetal growth, and modulates dopamine receptor trafficking in neurons.

In disease contexts, MAGED1 dysregulation is implicated in neurodevelopmental disorders (e.g., Prader-Willi-like syndrome), intellectual disability, and cancers such as melanoma and neuroblastoma. MAGED1 antibodies are essential tools for detecting protein expression via Western blotting, immunohistochemistry, and immunofluorescence. They aid in studying its localization (nucleus/cytoplasm), interaction partners, and tissue-specific roles. Recent research explores MAGED1’s therapeutic potential, including its use in CAR-T or vaccine-based strategies. However, challenges remain in understanding its isoform-specific functions and regulatory mechanisms. MAGED1 knockout mice exhibit metabolic and behavioral abnormalities, underscoring its multifaceted biological significance.