GAS2抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue , Primary antibody: P07311(GAS2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07311(GAS2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of GAS2 Antibody**

The Growth Arrest-Specific 2 (GAS2) protein, encoded by the *GAS2* gene, is a member of the GAS family implicated in cellular processes linked to growth arrest, cytoskeletal organization, and apoptosis. Initially identified for its upregulation during cell cycle arrest, GAS2 interacts with microtubules and microfilaments, playing a role in maintaining cytoskeletal architecture and mediating structural changes during apoptosis. Structurally, it contains a calponin homology (CH) domain for actin binding and a Gas2-like domain for microtubule association, enabling cross-linking of cytoskeletal components.

GAS2 antibodies are essential tools for studying its expression, localization, and function in cellular models. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore GAS2's regulatory roles in cell cycle arrest, apoptosis, and tissue development. Dysregulation of GAS2 has been associated with pathologies, including cancer and developmental disorders, making its antibody valuable in biomedical research. For instance, in cancer studies, GAS2 antibodies help assess its tumor-suppressive or oncogenic roles, depending on cellular context. Additionally, these antibodies aid in characterizing post-translational modifications (e.g., phosphorylation) that modulate GAS2 activity. Researchers prioritize antibodies validated for specificity, often targeting unique epitopes to avoid cross-reactivity with homologous proteins like GAS2L1 or GAS2L3. Overall, GAS2 antibodies are pivotal in unraveling cytoskeletal dynamics and their implications in health and disease.