EDN3抗体

+ +

•  

   

     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse eye tissue lysate, Primary antibody: P07286(EDN3 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07286(EDN3 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07286(EDN3 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

**Background of EDN3 Antibody**

Endothelin-3 (EDN3) is a 21-amino acid peptide belonging to the endothelin family, which includes EDN1. EDN2. and EDN3. These peptides bind to G protein-coupled receptors (EDNRA and EDNRB) to regulate diverse physiological processes, including vasoconstriction, cell proliferation, and neural crest cell development. EDN3 plays a critical role in the enteric nervous system (ENS) formation, melanocyte development, and cardiovascular function. Dysregulation of EDN3 signaling is linked to congenital disorders like Hirschsprung’s disease (characterized by aganglionic megacolon) and Waardenburg syndrome, as well as cancers such as melanoma and neuroendocrine tumors.

The EDN3 antibody is a targeted immunoassay tool designed to detect and quantify EDN3 protein expression in tissues or biological samples. It is commonly used in research to study EDN3’s spatial and temporal expression patterns, its interaction with receptors, and its involvement in developmental or pathological contexts. Polyclonal or monoclonal EDN3 antibodies are validated for techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). By enabling precise visualization of EDN3. these antibodies contribute to understanding its role in diseases and evaluating potential therapeutic strategies targeting the endothelin pathway.