DUSP4抗体

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     Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: RAW264.7 cells, Primary antibody: P07284(DUSP4 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P07284(DUSP4 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

DUSP4 (dual specificity phosphatase 4), also known as MKP-2. is a member of the dual-specificity phosphatase family that regulates mitogen-activated protein kinase (MAPK) signaling pathways, including ERK, JNK, and p38. It functions by dephosphorylating and inactivating MAPKs, thereby modulating cellular responses to stress, growth factors, and cytokines. DUSP4 is implicated in processes such as cell proliferation, differentiation, apoptosis, and immune regulation. Dysregulation of DUSP4 has been linked to various diseases, including cancer, inflammatory disorders, and neurodegenerative conditions, making it a focus of biomedical research.

The DUSP4 antibody is a critical tool for detecting and quantifying DUSP4 protein expression in experimental settings. It is widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to study tissue-specific expression, subcellular localization, and dynamic changes under physiological or pathological conditions. Researchers employ this antibody to explore correlations between DUSP4 levels and disease progression, therapeutic responses, or molecular mechanisms. For instance, in cancer studies, reduced DUSP4 expression has been associated with enhanced MAPK signaling and tumor aggressiveness. Commercially available DUSP4 antibodies are typically validated for specificity and sensitivity across species, particularly human and mouse models. Its utility extends to drug discovery, where it helps assess DUSP4-targeted therapeutic strategies aiming to restore MAPK pathway homeostasis.