DUSP14抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07281(DUSP14 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The DUSP14 antibody is a crucial tool in studying the dual-specificity phosphatase 14 (DUSP14), a member of the protein tyrosine phosphatase (PTP) family. DUSP14. also known as MKP6 or TEP, is a dual-specificity phosphatase that dephosphorylates both tyrosine and serine/threonine residues on mitogen-activated protein kinases (MAPKs), particularly JNK and p38. It plays a regulatory role in immune responses, cell proliferation, and apoptosis by modulating MAPK signaling pathways. DUSP14 is highly expressed in immune cells, including T cells and macrophages, and is implicated in inflammatory diseases, autoimmune disorders, and cancer progression.

The DUSP14 antibody is widely used in research to detect protein expression, localization, and activity in various biological samples. It aids in understanding DUSP14’s interaction with substrates, its role in signaling cascades, and its impact on disease mechanisms. Applications include Western blotting, immunohistochemistry, and flow cytometry. Researchers also utilize this antibody to explore DUSP14’s therapeutic potential, as its dysregulation correlates with conditions like rheumatoid arthritis, colitis, and hepatocellular carcinoma.

Validated for specificity and sensitivity, the antibody typically targets conserved epitopes in human, mouse, or rat DUSP14. Studies using knockout models or RNA interference further confirm its reliability. By enabling precise detection, the DUSP14 antibody supports advancements in immunology, oncology, and drug development, offering insights into targeted therapies for MAPK-related pathologies.