DUSP22抗体

The DUSP22 antibody is a crucial tool for studying dual-specificity phosphatase 22 (DUSP22), a protein encoded by the *DUSP22* gene, also known as JKAP or LMWDSP2. Belonging to the dual-specificity phosphatase family, DUSP22 regulates mitogen-activated protein kinase (MAPK) signaling pathways by dephosphorylating both tyrosine and serine/threonine residues on target kinases, including JNK, p38. and ERK. This phosphatase plays a role in immune response, cell proliferation, apoptosis, and stress signaling. Dysregulation of DUSP22 has been implicated in cancers, autoimmune disorders, and inflammatory diseases. Notably, chromosomal rearrangements involving *DUSP22* are linked to specific lymphomas, such as anaplastic large cell lymphoma (ALCL), making it a diagnostic marker. The DUSP22 antibody is widely used in immunohistochemistry (IHC), Western blotting, and immunofluorescence to assess protein expression, localization, and potential clinical correlations. Its application aids in understanding DUSP22's tumor-suppressive or oncogenic roles in different contexts, as well as its interaction with signaling networks. Researchers also utilize this antibody to explore therapeutic strategies targeting DUSP22-related pathways in precision medicine and drug development.