CAP1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P07149(CAP1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07149(CAP1 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07149(CAP1 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

CAP1 (adenylyl cyclase-associated protein 1) is a conserved eukaryotic protein involved in regulating actin dynamics and cellular signaling pathways. Initially identified in yeast, mammalian CAP1 plays a critical role in coordinating actin filament turnover by promoting cofilin-mediated severing and depolymerization of actin, essential for cell motility, cytokinesis, and vesicle trafficking. It also interacts with Ras GTPases and modulates cAMP signaling by associating with adenylyl cyclase, linking cytoskeletal reorganization to signal transduction.

CAP1 dysregulation has been implicated in various diseases. Overexpression is observed in cancers, correlating with tumor metastasis and poor prognosis, likely through enhanced cell migration and invasion. Its role in immune cell function, particularly T-cell activation and dendritic cell maturation, highlights connections to autoimmune and inflammatory disorders. Additionally, CAP1 interacts with huntingtin protein, suggesting relevance in neurodegenerative conditions like Huntington’s disease.

CAP1 antibodies are widely used in research to study protein expression, localization, and interactions via techniques such as Western blotting, immunofluorescence, and co-immunoprecipitation. Recent studies explore CAP1 as a therapeutic target, with inhibitors under investigation for cancer and immune-related pathologies. These antibodies remain crucial tools for elucidating CAP1’s multifaceted roles in cellular physiology and disease mechanisms.