BTG4抗体

The BTG4 antibody targets the B-cell translocation gene 4 (BTG4) protein, a member of the BTG/TOB family involved in cell cycle regulation, differentiation, and apoptosis. BTG4. also known as PC3B, interacts with the CCR4-NOT complex to modulate mRNA deadenylation and degradation, impacting gene expression post-transcriptionally. It plays critical roles in reproductive biology, particularly in oocyte maturation and early embryonic development. Studies link BTG4 dysfunction to female infertility, ovarian insufficiency, and embryonic lethality in animal models. In cancer research, BTG4 is considered a potential tumor suppressor, with reduced expression observed in malignancies like colorectal and gastric cancers. BTG4 antibodies are essential tools for detecting protein expression levels via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. They enable researchers to investigate BTG4's molecular mechanisms, its interaction partners, and its role in diseases. Commercial BTG4 antibodies are typically validated for specificity and sensitivity across human, mouse, and rat samples, supporting both basic research and clinical studies exploring diagnostic or therapeutic applications.