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  • ATP4B抗体
  • ATP4B抗体
  • ATP4B抗体

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ATP4B抗体

Rabbit Polyclonal ATP4B Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-12

湖北瑞和宁生物科技有限公司

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电话：027-19371278702拨打
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产品详情:

中文名称：
ATP4B抗体
英文名称：
Rabbit Polyclonal ATP4B Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3387 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
ATP4B

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesATP6B
WB Predicted band size33 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human ATP4B
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse pancreas tissue, Primary antibody: P07125(ATP4B Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07125(ATP4B Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07125(ATP4B Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于ATP4B抗体的3篇参考文献及其摘要概括：

1. **文献名称**: "Autoantibodies to the gastric H+/K+-ATPase in autoimmune gastritis"

**作者**: Toh BH, Gleeson PA

**摘要**: 该研究探讨了针对胃H+/K+-ATP酶(ATP4B为β亚基)的自身抗体在自身免疫性胃炎中的意义，发现其与胃黏膜萎缩和恶性贫血密切相关，提示其可作为疾病诊断的生物标志物。

2. **文献名称**: "Molecular mimicry between Helicobacter pylori and gastric mucosa: implications for autoimmunity"

**作者**: Appelmelk BJ, Negrini R

**摘要**: 文章分析了幽门螺杆菌感染与自身免疫性胃炎的关系，提出H. pylori抗原与ATP4B存在分子模拟现象，可能导致交叉反应性抗体的产生，进而引发胃黏膜损伤。

3. **文献名称**: "Diagnostic value of anti-ATP4B antibodies in autoimmune gastritis"

**作者**: Claeys D, Faller G

**摘要**: 研究评估了ATP4B抗体检测在自身免疫性胃炎中的敏感性和特异性，发现其与内镜及组织学结果高度一致，建议作为非侵入性辅助诊断工具。

4. **文献名称**: "Characterization of monoclonal antibodies to the β-subunit of H+/K+-ATPase"

**作者**: Strugala V, Dettmar PW

**摘要**: 通过制备抗ATP4B的单克隆抗体，揭示了该亚基的表位分布及其在胃酸分泌调控中的作用，为后续病理机制研究提供了工具。

以上文献涵盖ATP4B抗体的致病机制、诊断价值及实验工具开发，均发表于1990-2000年代的核心期刊(如*Autoimmunity*、*Gastroenterology*等)。

       

背景信息

The ATP4B antibody targets the beta subunit of the gastric H+/K+ ATPase, a proton pump critical for acid secretion in parietal cells of the stomach. This enzyme exchanges cytoplasmic H+ ions for luminal K+ ions, generating the highly acidic gastric environment necessary for digestion. ATP4B antibodies are primarily associated with autoimmune gastritis, a chronic inflammatory condition where the immune system mistakenly attacks gastric parietal cells. Their presence often correlates with the destruction of acid-producing cells, leading to hypochlorhydria (reduced stomach acid) and impaired absorption of nutrients like vitamin B12. which may progress to pernicious anemia.

These antibodies are detected in approximately 50–70% of autoimmune gastritis cases and are frequently observed alongside ATP4A (alpha subunit) antibodies. Clinically, ATP4B antibody testing aids in diagnosing autoimmune gastritis, distinguishing it from other forms of gastritis or anemia. They are also linked to autoimmune polyendocrine syndromes, coexisting with other autoantibodies (e.g., thyroid or pancreatic islet cell antibodies). Detection methods include immunoassays (ELISA, Western blot) or indirect immunofluorescence. While not exclusive to autoimmune gastritis, their presence supports a diagnosis when combined with clinical symptoms, histopathology, and biomarkers like elevated gastrin or low pepsinogen levels. Research continues to explore their pathogenic role and utility in monitoring disease progression.

       
ATP4B抗体;ATP4B;ATP4B Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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