SAR1B抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07107(SAR1B Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07107(SAR1B Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The SAR1B antibody is a crucial tool for studying the SAR1B protein, a member of the SAR1 GTPase family involved in intracellular vesicular transport. SAR1B, a key component of the COPII (coat protein complex II) machinery, facilitates the budding of transport vesicles from the endoplasmic reticulum (ER) to the Golgi apparatus. This process is essential for the secretion of proteins and lipids, including apolipoprotein B (apoB)-containing lipoproteins. Mutations in the SAR1B gene are linked to congenital disorders such as chylomicron retention disease (CMRD), a rare autosomal recessive condition characterized by lipid malabsorption, fat-soluble vitamin deficiencies, and failure to thrive in infants.

SAR1B antibodies are widely used in research to investigate the protein’s expression, localization, and function in cellular trafficking pathways. They enable techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess SAR1B levels in tissues or cultured cells, particularly in studies of lipid metabolism and ER-Golgi transport dynamics. Additionally, these antibodies aid in diagnosing genetic disorders by detecting aberrant SAR1B expression in patient-derived samples. By elucidating SAR1B’s role in COPII assembly and cargo selection, researchers gain insights into broader mechanisms of cellular secretion and related pathologies, including metabolic syndromes and neurodegenerative diseases. The antibody’s specificity and reliability make it indispensable for both basic research and clinical applications.